The NMN also known as nicotinamide mononucleot an organic molecule that is found throughout all living organisms. It is a crucial ingredient in the production of NAD+, which is a crucial coenzyme which is involved in more than 400 metabolic reactions within the human body.
There aren’t many studies that have examined the effects of NMN supplements on humans, research on animals has revealed a variety of NMN health advantages for rodents and different animals.
Animal research has proven that NMN can boost fertility and energy metabolism, memory cognition, as well as mitochondrial function. It also helps aid in treating obesity, aid in DNA repair, extend the lifespan, maintain stem cell health and lower the risk of developing heart disease.
Human studies have not found any adverse consequences of this supplement. A daily dose up to 500 mg is probably healthy for humans.
If you’re looking to test to test NMN on your own, then we recommend taking the GlycanAge test prior to and after completing the course of NMN to see if this supplement will have a positive impact on the biological age.
If you’ve ever spent a significant amount of time researching supplements that could improve your health, reduce the process of ageing and make you live longer, then you’ve likely encountered NMN. The supplement was popularized through the Dr. David Sinclair, a genetics professor at Harvard University and one of the top experts in the field of epigenetics and aging. Nowadays, biohackers, people who are interested in health and wellness and everyday people are adding NMN to their diets NMN hoping that it can help them keep their youthfulness the longest time possible. However, does the supplement perform as promised or is it simply another trend with no scientific evidence to support it? We examine this question more in detail in our post.
What’s NMN?
The NMN, also known as nicotinamide monnucleo is a ribonucleotide-containing chemical that is naturally found throughout all living organisms including humans. The molecule is composed of three groups: ribose Niotinamide, and Phosphate. NMN is vital for the survival of any organism as it is the precursor to NAD+, also known as nicotinamide adenine dinucleotide. NAD+ is among the most essential coenzymes within the body. It allows enzymes to catalyze various kinds of reactions. For example, NAD+ is essential to repair DNA and mitochondria function, which generates energy for the whole body.
A living organism isn’t possible without enzymes that aren’t able to catalyze the required reactions. That’s why it’s crucial that a person has an adequate supply of coenzymes as well as their precursors. As we age as we age, the amount of NAD+ within our bodies decreases and causes the development of illnesses. But we can reduce or stop harmful processes that result from the reduction of NAD+ concentrations by increasing the levels this coenzyme within our bodies.
What are the reasons to take NMN?
Although it may seem sensible to just consume NADsupplementation, that method isn’t effective since the coenzyme doesn’t pass through cell membranes before entering cells. This means that NAD+ supplements wouldn’t have any impact on the processes of cells or metabolism. It is better to consume NAD+ precursors. NMN is the most similar NAD+ precursor to the sequence of reaction needed to synthesize the coenzyme essential. When taken orally NMN is rapidly absorbed by your body and transformed to NAD+. For instance, researchers discovered increased concentrations of NAD+ in the livers of mice within 15 minutes.
As previously mentioned the body converts NMN to NAD+, a coenzyme which plays an essential role in hundreds of metabolic processes in the body. So, it’s no surprise that NMN supplements can have an impact on a variety of organs and processes within the body. Though the majority of studies conducted on supplements with NMN to date have been conducted in animals and have shown results that are hopeful. But, anyone who is thinking of taking NMN should be aware that scientists have to conduct more human studies to arrive at a definitive conclusion about the effectiveness and safety for NMN supplementation for human beings. In this regard this list of the most well-known examples of possible NMN benefits as of now:
NMN can reduce the risk of developing heart disease.
It is the primary reason for death among humans living in advanced countries So taking steps to ensure your blood vessels and heart are healthy is vital for living a long , healthy and happy life. Researchers have discovered that NMN was able to reduce the incidence of stiffening of blood vessels as well as reduce oxidative stress and alter the expression of genes in rodents.
Like other muscles you have it doesn’t receive no breaks or rest. This vital muscle requires a significant amount of energy in order to function. This is why the organ requires huge quantities of NMN which can be converted to NAD+. It could help in the energy metabolism. This implies that NMN can help improve the health of your heart and its function.
NMN can increase the energy metabolism
One of the major issues individuals face as they get older is a decrease in mobility and strength. This is due partly due to the fact that our bodies cease to generate enough energy to maintain the same level as earlier times and this causes an impairment in the muscle’s function. However, research studies conducted on mice have revealed an extended NMN supplementation increased the animal’s energy metabolism, without any obvious adverse consequences. Therefore, NMN might be able to aid humans in maintaining their energy levels at the peak of their lives. However, human research is essential to verify and test this theory.
NMN could help in reducing obesity
Obesity is a different issue that many people living in developed nations face. It’s no fact that the best method to avoid and treat obesity and related illnesses is to exercise regularly and adhere to a healthy and balanced diet, yet many have a difficult time implementing these changes , and they want to make use of other solutions in addition. Incredibly, studies on mice have revealed that NMN can have the same impact on the body to calories restriction. Should this result be observed for humans it could indicate that NMN is a feasible solution to improve the overall health and wellbeing for millions throughout the globe.
NMN could aid in DNA repair
Although DNA mutation may sound frightening, it’s a fact which happens to our bodies each and every day. DNA is continuously being damaged by mutagens , such as free radicals and ultraviolet light. Cells also frequently make mistakes while transcribing and replicating genetic material. Additionally, each time cells divide, telomeres which are DNA segments found at the ends of the molecules are made shorter. The shortening of telomeres and DNA mutations are all factors that result in the development of disease and the overall aging process of the body.
Our bodies continually attempt for the repair of DNA damaged and strengthen the telomeres by using sirtuin proteins. These proteins require NAD+ for their function. Several studies have demonstrated that mice fed NMN supplements had higher quantities of NAD+, as well as more active sirtuins and stabilized the telomeres.
NMN boosts mitochondrial function
If there’s one thing that everyone is aware of about mitochondria is that they’re the cell’s powerhouses that is, they transform the food we eat into energy for our cells. However, our mitochondria aren’t able to generate power without NAD+ and, if mitochondria in cells don’t perform their functions, the cell ceases to function. For instance, the dysfunction of mitochondria resulted from the lack of NAD+ levels in cell is linked to neurological diseases like Alzheimer’s. However, research has shown that administering NMN Supplements to mouse has the ability to bring back mitochondrial function.
NMN can have a positive impact on cognition and memory
One of the most significant challenges that comes with ageing is the decrease in cognitive capabilities and memory performance. Although some individuals can remain focused and retain their memories even after a long age, the majority of older people, unfortunately, discover that their brains not function at the same rate as they did when they were younger. However, recent studies of NMN results on mouse brains has revealed promising outcomes. According to research mice treated with NMN demonstrated an improvement in cognitive function, an increase in blood flow to the brain, as well as general improvement in brain functioning.
NMN helps to preserve the health of stem cells
Stem cells are vital to every organism since they allow our bodies to produce fresh cells and repair tissues and maintain our health. As you age the health that stem cells have decreases and they are unable to job at the same level as they did in the past. However, several studies have demonstrated that the increased amounts of NMN and NAD+ within the body were capable of improving the health of stem cells and increase the body’s self-renewal as well as self-healing abilities.
NMN can have a positive impact on fertility and libido
A decrease in libido as well as fertility levels is another negative effect of aging. It is interesting to note that many who regularly consume NMN supplement have noticed an increase in their libido. It’s crucial to remember that this is only speculation that isn’t confirmed by any research currently. There is however some scientific evidence to suggest that this supplement could increase fertility and even improve it in old animals.
NMN can prolong the lifespan
NMN has also been proven to prolong the life span of worms, mice and yeast. It could be an effect that is synergetic with all other health benefits associated with this supplement.